EFFECTS OF FLUORODEOXYURIDINE ON DNA REPLICATION, CHROMOSOME BREAKAGE, AND REUNION
نویسندگان
چکیده
منابع مشابه
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Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication
Telomeres, the ends of linear eukaryotic chromosomes, have a specialized chromatin structure that provides a stable chromosomal terminus. In budding yeast Rap1 protein binds to telomeric TG repeat and negatively regulates telomere length. Here we show that binding of multiple Rap1 proteins stimulates DNA double-stranded break (DSB) induction at both telomeric and non-telomeric regions. Consiste...
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15 صفحه اولReplication Stress-Induced Chromosome Breakage Is Correlated with Replication Fork Progression and Is Preceded by Single-Stranded DNA Formation
Chromosome breakage as a result of replication stress has been hypothesized to be the direct consequence of defective replication fork progression, or "collapsed" replication forks. However, direct and genome-wide evidence that collapsed replication forks give rise to chromosome breakage is still lacking. Previously we showed that a yeast replication checkpoint mutant mec1-1, after transient ex...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1962
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.48.2.190